Leishmania (Leishmania) mexicana causes cutaneous leishmaniasis, an endemic zoonosis affecting a growing number of patients in the southeastern states of Mexico.Some foci are found in shade-grown cocoa and coffee plantations, or near perennial forests that provide rich breeding grounds for the sand fly vectors, but also harbor a variety of bat spec
Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells.
The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (IKr) and contributes to phase III cardiac action potential repolarization.Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes.Berberine (BBR) has multiple actions, and its hydrogenated derivative dihydroberberin
Role of the Combination of Cyclin-Dependent Kinase Inhibitors (CDKI) and Radiotherapy (RT) in the Treatment of Metastatic Breast Cancer (MBC): Advantages and Risks in Clinical Practice
Targeting cell cycle has become the gold standard for metastatic breast cancer (MBC), being cyclin-dependent kinase inhibitors (CDKIs) cornerstones of its treatment, alongside radiotherapy (RT).To date, no definite evidence regarding safety and efficacy of the combination of CDKIs plus radiotherapy (RT) is currently available.Purpose of this review
Eco-geological environment quality assessment in a mining city: a case study of Jiangxia District, Wuhan City
This study investigates the eco-geological environmental challenges faced by Jiangxia District, a mining region in Wuhan City.By combining field CREAM surveys, literature analysis and multi-source data such as remote sensing images and on-site monitoring data, an eco-geological environment quality (EGEQ) assessment system was developed.The system c